Preimplantation Genetic Testing (PGT): What To Know

Embryo preimplantation testing, also known as Preimplantation Genetic Testing (PGT), plays a crucial role in the field of in vitro fertilization (IVF) by allowing people to identify and select embryos with the highest chance of successful implantation. In this blog post, we will delve into the details of PGT, discussing what it entails, how it is conducted, and the various types of genetic testing available.

What is Preimplantation Genetic Testing (PGT)?

Preimplantation Genetic Testing (PGT) refers to the procedure of screening embryos created through IVF for genetic abnormalities before implantation in the uterus. PGT enables prospective parents to identify genetic conditions and chromosomal abnormalities in embryos, helping them make informed decisions about embryo selection and family planning.

How is Genetic Testing for IVF Done?

The process of genetic testing for IVF involves several steps. First, during an IVF cycle, embryos are cultured in a laboratory. Then, on day 5 or 6, a few cells are carefully removed from each embryo for genetic analysis. These cells are sent to a specialized laboratory where the genetic material is examined for specific genetic conditions or chromosomal abnormalities. The results of the analysis provide valuable information about the genetic health of each embryo.

What Does PGT Test For?

Preimplantation Genetic Testing serves different purposes based on the specific type of testing conducted. Let’s explore the three main types:

Preimplantation Genetic Testing for Aneuploidy (PGT-A)

PGT-A aims to identify chromosomal abnormalities in embryos, such as extra or missing chromosomes. These abnormalities can lead to implantation failure, miscarriage, or genetic disorders. By selecting embryos with a normal chromosomal makeup, the chances of a successful pregnancy can be significantly increased.

Who Should Get PGT-A?

PGT-A is recommended for couples who have experienced repeated implantation failures, recurrent miscarriages, or are of advanced maternal age. It can also be beneficial for individuals with a history of chromosomal abnormalities or genetic disorders in their family.

Preimplantation Genetic Testing for a Monogenic Disease (PGT-M)

PGT-M is specifically designed to identify single-gene disorders in embryos. It allows couples who are carriers of certain genetic conditions to select embryos that are free from the particular genetic disease they carry, thus reducing the risk of passing it on to their children.

Who Should Get PGT-M?

PGT-M is recommended for couples who have a known genetic disorder or are carriers of a specific genetic condition. It enables them to choose embryos unaffected by the particular disease, ensuring the health of their future child.

PGT for Chromosome Structural Rearrangement (PGT-SR)

PGT-SR is performed when one or both parents have a structural rearrangement of their chromosomes, such as translocations or inversions. This testing allows the identification of embryos with balanced chromosome arrangements, reducing the risk of chromosomal abnormalities and increasing the chances of successful pregnancy.

Who Should Get PGT-SR?

PGT-SR is recommended for couples with known chromosomal rearrangements. It helps them select embryos that are balanced or unaffected, thereby minimizing the risk of miscarriage or implantation failure.

How Much Does Genetic Testing for IVF Cost?

The cost of genetic testing for IVF can vary depending on several factors, including the type of testing, the number of embryos analyzed, and the geographic location of the clinic. On average, the cost can range from $4,000 to $10,000 per IVF cycle. It’s important to consult with your fertility clinic to get accurate pricing information and understand any additional costs that may be involved.

Sunfish is here to help provide the resources you need to cover the costs of all things IVF. If you have questions about how to pay for PGT-A testing or cover any other costs on your fertility journey, we can schedule a complimentary consultation with you to answer them and go over your financial planning options.